Department of Pathology
The University of Chicago
Knapp Center for Biomedical Discovery (KCBD)
900 East 57th Street
MC 1059, Room 5102
Chicago, IL 60637
Cardiac Pathology, including congenital heart disease and adult cardiac pathology.
What are the molecular pathways that dictate cardiac morphogenesis? What is the developmental ontogeny of Congenital Heart Disease (CHD), the number one birth defect world-wide? How did the cardiovascular system evolve into a form that can support terrestrial life? These intertwined questions form the basis for the investigations underway in the Moskowitz laboratory.
Gene Discovery for CHD
We performed a gene discovery program using a forward genetic screen in mice to identify CHD-causing mutations (Kamp et al., 2010). Our initial work was the first to link cilia signaling to heart development (Friedand-Little et al., 2011). We have recently identified the CHD-causing mutations in multiple lines and are studying their effects on cardiac morphogenesis. This work has led us to the importance of gene regulatory networks in the Second Heart Field for atrial septation.
Cardiac Progenitor Specification and Cardiac Morphogenesis
Our recent work (Hoffmann et al., 2009 and Xie et al., 2012) suggests that the molecular logic governing cardiac septation is firmly established within cardiac progenitors long before septum morphogenesis occurs. In current studies we are using genomic techniques to uncover the molecular programs required in cardiac progenitors for septum morphogenesis.
Cardiac Conduction System
The Cardiac Conduction System (CCS) is a specialized network of cardiomyocytes responsible for coordinating the rhythmic contraction of the heart. We have generated novel transgenic mouse lines for CCS-specific studies (Arnolds and Moskowitz, 2011) and used them to identify a molecular pathway required for adult CCS function (Arnolds et al., 2012). We are continuing these studies to unveil the molecular logic underlying CCS function.
Our laboratory studies basic questions in cardiac development and function. We take biochemical, molecular, genetic, genomic and cellular approaches to these problems. Our aims are to elucidate general principles of organ morphogenesis using the heart as a model, understand the ontogeny of Congenital Heart Disease, and contribute to our understanding of cardiac evolution. For more information, contact Ivan at email@example.com.