Director, Division of Genomic and Molecular Pathology
Department of Pathology
The University of Chicago
5841 S. Maryland Ave.
MC 1089, Room P-313
Chicago, IL 60637
Jeremy Segal, MD, PhD is the Director of the Division of Genomic and Molecular Pathology. Genomic and Molecular Pathology was created in order to bring together the latest in genomics technologies, computational biology approaches and scientific knowledge for the care of patients at the University of Chicago and the broader community. Today, it is well understood that the best hope for the treatment of many illnesses depends upon having the best possible information, both about the patient as well as his or her particular condition. For cancer and a host of other diseases, genetic information is a critical piece of the puzzle, and can help to better define disease, predict its progression and most importantly help to select the best possible treatment for each individual patient. Modern genomics technologies can provide unprecedented windows into the biology of disease processes. As a molecular pathologist in the division's Clinical Genomics Laboratory, Dr. Segal's clinical interest is in developing new genomic analysis tools and bioinformatics systems utilizing this technology to help support the care of University of Chicago patients. For more information about Genomic and Molecular Pathology, click here http://gmp.uchicago.edu
Dr. Segal's research interests dovetail with his clinical focus and is mainly related to the development of novel genomic analysis technologies for cancer. Current efforts are focused on development of assays to detect trace cancer signals, including minimal residual disease, therapy resistance mutations and circulating plasma tumor DNA.
- Schramek D, Sendoel A, Segal JP, Beronja S, Heller E, Oristian D, Reva B, Fuchs E. Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas. Science. 2014 Jan 17;343(6168):309-13.
- Keyes BE, Segal JP, Heller E, Lien WH, Chang CY, Guo X, Oristian DS, Zheng D, Fuchs E. Nfatc1 orchestrates aging in hair follicle stem cells. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E4950-9.
- Lyon GJ and Segal JP. Practical, ethical and regulatory considerations for the evolving medical and research genomics landscape. Applied and Translational Genomics. 2013.
- Preminger BA, Hiltzik DH, Segal JP, Morrison NG. An operative approach to the treatment of cutaneous nasal sarcoid: a case report and review of the literature. Ann Plast Surg. 2009 Dec;63(6):685-7.
- Olson WC, Rabut GE, Nagashima KA, Tran DN, Anselma DJ, Monard SP, Segal JP, Thompson DA, Kajumo F, Guo Y, Moore JP, Maddon PJ, Dragic T. Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5. J Virol. 1999 May;73(5):4145-55.
- Ogg GS, Jin X, Bonhoeffer S, Moss P, Nowak MA, Monard S, Segal JP, Cao Y, Rowland-Jones SL, Hurley A, Markowitz M, Ho DD, McMichael AJ, Nixon DF. Decay kinetics of human immunodeficiency virus-specific effector cytotoxic T lymphocytes after combination antiretroviral therapy. J Virol. 1999 Jan;73(1):797-800.
- Ogg GS, Jin X, Bonhoeffer S, Dunbar PR, Nowak MA, Monard S, Segal JP, Cao Y, Rowland-Jones SL, Cerundolo V, Hurley A, Markowitz M, Ho DD, Nixon DF, McMichael AJ. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science. 1998 Mar 27;279(5359):2103-6.