Megan McNerney, MD, PhD

Assistant Professor

Department of Pathology
The University of Chicago
Knapp Center for Biomedical Discovery (KCBD)
900 E. 57th Street, Room 5128
Chicago, IL 60637
Phone: 773.834.8896

Dr. Megan McNerney received her BA at Northwestern University and M.D. and Ph.D. at the University of Chicago.  As an Immunology Ph.D. student in the lab of Vinay Kumar, M.D., M.B.B.S., she studied how natural killer cells eliminate tumor cells, and discovered a novel system of natural killer cell inhibition.  She completed her postdoctoral work in Dr. Kevin White’s laboratory within the Institute of Genomics and Systems Biology at the University of Chicago, where she characterized the genetic abnormalities in high-risk myeloid neoplasm.  Dr. McNerney is a Leukemia and Lymphoma Society Fellow and was named the 2013 Leukemia and Lymphoma Society, Illinois Chapter, Researcher of the Year.  She is a recent recipient of the Cancer Research Foundation Young Investigator Award and Riviera Country Club United-4 A Cure Award.  Other honors include the Robert W. Wissler Fellowship Award, the Leon O. Jacobson Basic Science Prize, the Robert E. Priest Pathology Merit Award, the Elaine Frank Family Fellowship for Medical Research, and the College of American Pathologists Resident Research Grant.

Clinical Interests

  • Genomic and Molecular Pathology
  • Hematopoietic Malignancy Genomics

Dr. McNerney is board-certified in Clinical Pathology and is an Attending in the Genomic and Molecular Pathology clinical diagnostic lab.  Her clinical role is identifying cancer mutations, by next-generation sequencing, to guide patient diagnosis and treatment decisions.

Research Interest

The McNerney lab studies the genomic changes in blood cancers with the goal of identifying therapeutic vulnerabilities.  We focus on myeloid malignancies which are particularly difficult to treat.  We apply a variety of functional genomics approaches and model systems to decipher changes in the cancer genome.  Ongoing and available projects include studies of hematopoietic stem cell regulation, gene regulation during hematopoiesis, contiguous gene syndromes in cancer, and oncogenic signaling.  Please visit our webpage for more information

Selected Papers

Pubmed link to M. McNerney's publications