Shu-Yuan Xiao, MD


Department of Pathology
The University of Chicago
5841 S. Maryland Avenue
MC 6101, Room E-607B
Chicago, IL 60637
Phone: 773.702.1614
Fax: 773.702.1243

Clinical Interests 

Dr. Xiao is an expert pathologist with interests in tumors and non-neoplastic diseases of the gastrointestinal tract, hepatobiliary system, and pancreas. 

Research Interests 

Pathology and pathogenesis of gastrointestinal and hepatobiliary diseases; new markers for differential diagnosis of tumors; pathogenesis of viral diseases.


Xiao S-Y, Oshima K. LIVER PATHOLOGY. Demos Surgical Pathology Guides.  DemosMEDICAL, New York.  2014

Xiao S-Y. Color Atlas and Synopsis: Gastrointestinal Pathology. McGraw-Hill, New York. 2015

Selected Published Papers

1.      Raju GS, Ahmed I, Brining DL, Xiao S-Y.  Endoluminal closure of a large perforation of colon in a porcine model (+video). Gastrointestional Endoscopy. 64(4): 640-6; 2006.

2.      Ge Y, Rampy BA, Wang HL, Xiao S-Y.  Reduced CD1d expression in colonic epithelium in microscopic colitis.  Appl Immunohistochem Mol Morphol. 14(3): 309-13; 2006.

3.      Xu FL, Chen HL, Travassos da Rosa APA, Tesh RB, and Xiao S-Y.  Phylogenetic relationships among sandfly fever group viruses (Phlebovirus; Bunyaviridae) based on the small genome segment. J Gen Virol. 88(8): 2312-2319; 2007.

4.      Ryan MW, Cunningham S, Xiao SY. Maxillary sinus melanoma as the presenting feature of Carney complex. Int J Pediatr Otorhinolaryngol 72(3):405-408; 2008.

5.      Xu F, Tesh RB, Xiao S-Y. Characterization of cell death pathways in Punta Toro virus (Adames strain)-induced hepatocyte injury. J Gen Virol. 89: 2175 – 2181; 2008

6.      Ma H, Gomez V, Lu L, Yang X, Wu X, and Xiao S-Y.  Expression of adiponectin and its receptors in livers of morbidly obese patients with non-alcoholic fatty liver disease.  J Gastroent and Hepat. 24(2):233-7; 2008

7.      Wu X, Lu L, Guzman, H, Tesh RB, and Xiao S-Y. Persistent infection and associated nucleotide changes of West Nile virus serially passaged in hamsters. J Gen Virol. 89(12): 3073-9; 2008

8.      Snyder N, Martinez JG, Xiao S-Y. Chronic hepatitis C is common associated with hepatic granulomas.  World J Gastroenterol. 14(41): 6366-9; 2008

9.      Rychahou P, Kang J-H, Gulhati P, Doan H, Chen A, Xiao S-Y, Chung D, Evers, B. AKT2 overexpression plays a critical role in the establishment of colorectal cancer metastasis. Proc Natl Acad Sci U S A.  105 (51): 20315-20; 2008

10.  Liang Y, Shilagard T, Xiao SY, Snyder N, Lau D, Cicalese L, Weiss H, Vargas G, Lemon SM. Visualizing Hepatitis C Virus Infections in Human Liver by Two-Photon Microscopy.  Gastroenterology. 137(4):1448-58; 2009

11.  Yan BC, Gong C, Song J, Krausz T, Tretiakova M, Hyjek E, Al-Ahmadie H, Alves V, Xiao SY, Anders RA, Hart JA.  Arginase-1: a new immunohistochemical marker of hepatocytes and hepatocellular neoplasms.  Am J Surg Pathol. 2010; 34(8):1147-54.

12.  Li M, Song J, Mirkov S, Xiao SY, Hart J and Liu W.  Comparing Morphometric, Biochemical and Visual Measurements of Macrovesicular Steatosis of Liver.  Human Path 2011; 42(3): 356-60.

13.  Chennat J, Konda VJ, Madrigal-Hoyos E, Fernandez-Sordo J, Xiao SY, Hart J, Waxman I. Biliary confocal laser endomicroscopy real-time detection of cholangiocarcinoma.  Dig Dis Sci. 2011; 56(12): 3701-6. 

14.  Catenacci D, Henderson L, Xiao SY, Penuel E, Patel P, Yauch R, Peterson A, and Salgia R. Durable complete response of metastatic gastric cancer with anti-MET therapy followed by resistance at recurrence. Cancer Discovery 2011; 1(7):573-9.

15.  Tretiakova, M, Antic T, Mueller J, Himmelfarb EA, Wang HL, Xiao SY. Diagnostic utility of CD10 in benign and malignant extrahepatic bile duct lesions. Am J Surg Pathol 2012; 36(1): 101-8

16.  Landau M, Goldblum JR, DeRoche T, Dumot J, Downs-Kelly E, Rice TW, Xiao SY, Liu X. Esophageal carcinoma cuniculatum: report of 9 cases. Am J Surg Pathol 2012; 36(1): 8-17.

17.  Pai RK, Rybicki L, Goldblum JR, Shen B, Xiao SY, Liu X. Paneth cells in colonic adenomas: association with male sex and adenoma burden. Am J Surg Pathol 2013; 37(1): 98-103.

18.  Xiao S-Y. Intraductal papillary mucinous neoplasm of the pancreas: an update. Spotlight Article for Scientifica (Invited review).  2012; 20 pages. (

19.  Xiao SY, Zhao L, Hart J, Semrad C.  Gastric mucosal necrosis with vascular degeneration induced by doxycycline.  Am J Surg Pathol 2013; 37(2): 259-263.

20.  Liu X, Xiao SY, Plesec T, Lazenby A.  Collagenous colitis in children and adolescents: a study of 7 cases and literature review.  Modern Pathology 2013; 26 (6):881-7.

21.  Chen D, Xie H, Goldblum JR, Landau M, Rice TW, Pai R, Xiao SY, Liu X. Semiquantitative evaluation of a common histology pattern improves diagnosis of esophageal carcinoma cuniculatum in mucosal biopsy. Modern Path 2013; 26(6): 806-15.

22.  Xiao SY, Zhao L, Hart J, Semrad CE.  Doxycycline-induced gastric and esophageal mucosal injuries with vascular degeneration (Letter to editor).  Am J Surg Pathol 2013; 37(7): 1115-6.

23.  Jiang W, Roma AA, Lai K, Carver P, Xiao SY, Liu X. Endometriosis involving the mucosa of the intestinal tract - a clinicopathologic study of 15 cases.  Modern Pathol 2013; 26(9): 1270-8.

24.  Whitcomb E., Liu X, Xiao SY. Crohn enteritis-associated small bowel adenocarcinomas exhibit gastric differentiation. Human Pathol 2014; 45(2):359-67

25.  Xie H, Xiao SY, Pai R, Jiang W, Shadrach B, Carver P, Wang Y, Shen B, Liu XL. Diagnostic utility of p53 and cytokeratin 7 immunohistochemistry in idiopathic inflammatory bowel disease-associated neoplasia.  Modern Pathol 2014; 27(2):303-13

26.  Zhang X, Liu X, Joseph L, Hart J, Xiao SY. Pancreatic ductal adenocarcinoma with autoimmune pancreatitis-like histological and immunohistochemical features. Human Pathol 2014; 45(3):621-7

27.  Petersen JR, Stevenson HL,  Kasturi K, Naniwadekar A, Parkes J, Cross R, Rosenberg W,  Xiao SY, Snyder N. Evaluation of the APRI (AST, platelet ratio index) and ELF™ (Enhanced Liver Fibrosis) tests to detect significant fibrosis due to chronic hepatitis C. J Clin Gastroenterol 2014; 48:370-6.

28.  Chiu AS, Bluhm D, Xiao SY, Waxman I, Matthews JB. Enteric duplication cyst of the pancreas associated with chronic pancreatitis and pancreatic cancer. J Gastroint Surg 2014; 18(5):1054-8.

29.  Konda V, Gonzalez M, Koons A, Hart J, Xiao SY, Siddiqui U, Ferguson M, Posner M, Patti M, Waxman I. Complete endoscopic mucosal resection is effective and durable treatment for Barrett's-associated neoplasia.  Clin Gastroenterol Hepatol  2014; 12:2002-10.

30.  Konda VJ, Koons A, Siddiqui UD, Xiao SY, Turner JR, Waxman I. Optical biopsy approaches in Barrett's esophagus with next-generation optical coherence tomography. Gastrointestinal Endoscopy. 2014; 80(3):516-7.

31.  Catenacci DV, Liao WL, Thyparambil S, Henderson L, Xu P, Zhao L, Rambo B, Hart J, Xiao SY, Bengali K, Uzzell J, Darfler M, Krizman DB, Cecchi F, Bottaro DP, Karrison T, Veenstra TD, Hembrough T, Burrows J. Absolute Quantitation of Met Using Mass Spectrometry for Clinical Application: Assay Precision, Stability, and Correlation with MET Gene Amplification in FFPE Tumor Tissue.   PLoS ONE  2014; 9(7):e100586.