People

Albert Bendelac, MD PhD

  • A.N. Pritzker Distinguished Service Professor of Pathology
  • Research and Scholarly Interests: B cells, Innate lymphocytes, Intestinal IgA B cells, Intestinal intraepithelial T cells, Lymphocyte development, Microbiome, NKT cells, T cells
  • Websites: Bendelac Lab, Research Network Profile
  • Contact: abendela@bsd.uchicago.edu

Our laboratory studies the populations of lymphocytes that reside at mucosal barriers and perform rapid innate-like functions to maintain homeostasis and protect against infection, injury and tumor. We use developmental biology and genetic engineering to define the identity and track the function of multiple ‘unconventional’ populations including NKT cells, MAIT cells, gamma-delta T cells, innate lymphoid cells, intraepithelial intestinal T lymphocytes and IgA producing intestinal B cells. Ultimately, these studies help identify the central relationships between immunity and microbiome at the intestinal barrier.

University Paris VI
Paris, France
MD - Medicine
06/1985

University Paris VII
Paris, France
PhD - Immunology
06/1992

Intrinsic functional defects of type 2 innate lymphoid cells impair innate allergic inflammation in promyelocytic leukemia zinc finger (PLZF)-deficient mice.
Verhoef PA, Constantinides MG, McDonald BD, Urban JF, Sperling AI, Bendelac A. Intrinsic functional defects of type 2 innate lymphoid cells impair innate allergic inflammation in promyelocytic leukemia zinc finger (PLZF)-deficient mice. J Allergy Clin Immunol. 2016 Feb; 137(2):591-600.e1.
PMID: 26602165

Natural polyreactive IgA antibodies coat the intestinal microbiota.
Bunker JJ, Erickson SA, Flynn TM, Henry C, Koval JC, Meisel M, Jabri B, Antonopoulos DA, Wilson PC, Bendelac A. Natural polyreactive IgA antibodies coat the intestinal microbiota. Science. 2017 10 20; 358(6361).
PMID: 28971969

Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A.
Bunker JJ, Flynn TM, Koval JC, Shaw DG, Meisel M, McDonald BD, Ishizuka IE, Dent AL, Wilson PC, Jabri B, Antonopoulos DA, Bendelac A. Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A. Immunity. 2015 Sep 15; 43(3):541-53.
PMID: 26320660

Diverse developmental pathways of intestinal intraepithelial lymphocytes.
McDonald BD, Jabri B, Bendelac A. Diverse developmental pathways of intestinal intraepithelial lymphocytes. Nat Rev Immunol. 2018 08; 18(8):514-525.
PMID: 29717233

Elevated T cell receptor signaling identifies a thymic precursor to the TCRaß(+)CD4(-)CD8ß(-) intraepithelial lymphocyte lineage.
McDonald BD, Bunker JJ, Ishizuka IE, Jabri B, Bendelac A. Elevated T cell receptor signaling identifies a thymic precursor to the TCRaß(+)CD4(-)CD8ß(-) intraepithelial lymphocyte lineage. Immunity. 2014 Aug 21; 41(2):219-29.
PMID: 25131532

Crystal structure of Vd1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human ?d T cells.
Luoma AM, Castro CD, Mayassi T, Bembinster LA, Bai L, Picard D, Anderson B, Scharf L, Kung JE, Sibener LV, Savage PB, Jabri B, Bendelac A, Adams EJ. Crystal structure of Vd1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human ?d T cells. Immunity. 2013 Dec 12; 39(6):1032-42.
PMID: 24239091

The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vd1 TCR.
Bai L, Picard D, Anderson B, Chaudhary V, Luoma A, Jabri B, Adams EJ, Savage PB, Bendelac A. The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vd1 TCR. Eur J Immunol. 2012 Sep; 42(9):2505-10.
PMID: 22829134

Selection and expansion of CD8alpha/alpha(1) T cell receptor alpha/beta(1) intestinal intraepithelial lymphocytes in the absence of both classical major histocompatibility complex class I and nonclassical CD1 molecules.
Park SH, Guy-Grand D, Lemonnier FA, Wang CR, Bendelac A, Jabri B. Selection and expansion of CD8alpha/alpha(1) T cell receptor alpha/beta(1) intestinal intraepithelial lymphocytes in the absence of both classical major histocompatibility complex class I and nonclassical CD1 molecules. J Exp Med. 1999 Sep 20; 190(6):885-90.
PMID: 10499927

SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics.
Verykokakis M, Boos MD, Bendelac A, Kee BL. SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics. Immunity. 2010 Aug 27; 33(2):203-15.
PMID: 20674402

Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells.
Verykokakis M, Boos MD, Bendelac A, Adams EJ, Pereira P, Kee BL. Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells. PLoS One. 2010 Feb 19; 5(2):e9303.
PMID: 20174563

View All Publications

Quantrell Teaching Award
University of Chicago
2019

MERIT Award
National Institutes of Health
2017

A.N. Pritzker Professorship
University of Chicago
2008 - pres

Howard Hughes Medical Investigator
2005 - 2013

Cancer Research Institute Investigator Award
1995 - 1998

Mallinkrodt Foundation Award
1994 - 1997

Gold Medal of the Residency Program
Assistance Publique Hopitaux de Paris
1988

Oulmont, Laval, Dreyfous Prize
Academie of Medicine Paris
1988