Innate and Innate-Like Lymphocytes
Our laboratory studies the populations of lymphocytes that reside at mucosal barriers and perform rapid innate-like functions to maintain homeostasis and protect against infection, injury and tumor. We use developmental biology and genetic engineering to define the identity and track the function of multiple ‘unconventional’ populations including NKT cells, MAIT cells, gamma-delta T cells, innate lymphoid cells, intraepithelial intestinal T lymphocytes and IgA producing intestinal B cells. Ultimately, these studies help identify the central relationships between immunity and microbiome at the intestinal barrier.
University Paris VII
Paris, France
PhD - Immunology
1992
University Paris VI
Paris, France
MD - Medicine
1985
GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology.
GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology. Immunity. 2023 01 10; 56(1):43-57.e10.
PMID: 36630917
The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe.
The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe. Proc Natl Acad Sci U S A. 2021 09 28; 118(39).
PMID: 34548394
A Gata3 enhancer necessary for ILC2 development and function.
A Gata3 enhancer necessary for ILC2 development and function. Proc Natl Acad Sci U S A. 2021 08 10; 118(32).
PMID: 34353913
Synthesis of the pentasaccharide repeating unit from Ruminococcus gnavus and measurement of its inflammatory properties.
Synthesis of the pentasaccharide repeating unit from Ruminococcus gnavus and measurement of its inflammatory properties. RSC Adv. 2021 Apr 15; 11(24):14357-14361.
PMID: 35424013
Multi-transcription factor reporter mice delineate early precursors to the ILC and LTi lineages.
Multi-transcription factor reporter mice delineate early precursors to the ILC and LTi lineages. J Exp Med. 2021 02 01; 218(2).
PMID: 33104170
Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops.
Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops. Elife. 2020 11 10; 9.
PMID: 33169668
B cell superantigens in the human intestinal microbiota.
B cell superantigens in the human intestinal microbiota. Sci Transl Med. 2019 08 28; 11(507).
PMID: 31462512
IgA Responses to Microbiota.
IgA Responses to Microbiota. Immunity. 2018 08 21; 49(2):211-224.
PMID: 30134201
Diverse developmental pathways of intestinal intraepithelial lymphocytes.
Diverse developmental pathways of intestinal intraepithelial lymphocytes. Nat Rev Immunol. 2018 08; 18(8):514-525.
PMID: 29717233
Publisher Correction: A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development.
Publisher Correction: A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development. Nat Commun. 2017 11 30; 8(1):1933.
PMID: 29192205
Quantrell Teaching Award
University of Chicago
2019
MERIT Award
National Institutes of Health
2017
A.N. Pritzker Professorship
University of Chicago
2008 - pres
Howard Hughes Medical Investigator
2005 - 2013
Cancer Research Institute Investigator Award
1995 - 1998
Mallinkrodt Foundation Award
1994 - 1997
Gold Medal of the Residency Program
Assistance Publique Hopitaux de Paris
1988
Oulmont, Laval, Dreyfous Prize
Academie of Medicine Paris
1988