People

Albert Bendelac, MD PhD

  • A.N. Pritzker Distinguished Service Professor of Pathology
    Committee on Immunology
  • Research and Scholarly Interests: B cells, Innate lymphocytes, Intestinal IgA B cells, Intestinal intraepithelial T cells, Lymphocyte development, Microbiome, NKT cells, T cells
  • Websites: Bendelac Lab, Research Network Profile
  • Contact: abendela@bsd.uchicago.edu
  • Graduate Program: Immunology

Innate and Innate-Like Lymphocytes

Our laboratory studies the populations of lymphocytes that reside at mucosal barriers and perform rapid innate-like functions to maintain homeostasis and protect against infection, injury and tumor. We use developmental biology and genetic engineering to define the identity and track the function of multiple ‘unconventional’ populations including NKT cells, MAIT cells, gamma-delta T cells, innate lymphoid cells, intraepithelial intestinal T lymphocytes and IgA producing intestinal B cells. Ultimately, these studies help identify the central relationships between immunity and microbiome at the intestinal barrier.

University Paris VII
Paris, France
PhD - Immunology
1992

University Paris VI
Paris, France
MD - Medicine
1985

The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe.
Borowska MT, Drees C, Yarawsky AE, Viswanathan M, Ryan SM, Bunker JJ, Herr AB, Bendelac A, Adams EJ. The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe. Proc Natl Acad Sci U S A. 2021 09 28; 118(39).
PMID: 34548394

A Gata3 enhancer necessary for ILC2 development and function.
Kasal DN, Liang Z, Hollinger MK, O'Leary CY, Lisicka W, Sperling AI, Bendelac A. A Gata3 enhancer necessary for ILC2 development and function. Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32).
PMID: 34353913

Multi-transcription factor reporter mice delineate early precursors to the ILC and LTi lineages.
Kasal DN, Bendelac A. Multi-transcription factor reporter mice delineate early precursors to the ILC and LTi lineages. J Exp Med. 2021 02 01; 218(2).
PMID: 33104170

Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops.
Boughter CT, Borowska MT, Guthmiller JJ, Bendelac A, Wilson PC, Roux B, Adams EJ. Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops. Elife. 2020 11 10; 9.
PMID: 33169668

B cell superantigens in the human intestinal microbiota.
Bunker JJ, Drees C, Watson AR, Plunkett CH, Nagler CR, Schneewind O, Eren AM, Bendelac A. B cell superantigens in the human intestinal microbiota. Sci Transl Med. 2019 08 28; 11(507).
PMID: 31462512

IgA Responses to Microbiota.
Bunker JJ, Bendelac A. IgA Responses to Microbiota. Immunity. 2018 08 21; 49(2):211-224.
PMID: 30134201

Diverse developmental pathways of intestinal intraepithelial lymphocytes.
McDonald BD, Jabri B, Bendelac A. Diverse developmental pathways of intestinal intraepithelial lymphocytes. Nat Rev Immunol. 2018 08; 18(8):514-525.
PMID: 29717233

Publisher Correction: A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development.
Mao AP, Ishizuka IE, Kasal DN, Mandal M, Bendelac A. Publisher Correction: A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development. Nat Commun. 2017 11 30; 8(1):1933.
PMID: 29192205

NKT cells contribute to basal IL-4 production but are not required to induce experimental asthma.
McKnight CG, Morris SC, Perkins C, Zhu Z, Hildeman DA, Bendelac A, Finkelman FD. NKT cells contribute to basal IL-4 production but are not required to induce experimental asthma. PLoS One. 2017; 12(11):e0188221.
PMID: 29182669

A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development.
Mao AP, Ishizuka IE, Kasal DN, Mandal M, Bendelac A. A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development. Nat Commun. 2017 10 16; 8(1):863.
PMID: 29038474

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Quantrell Teaching Award
University of Chicago
2019

MERIT Award
National Institutes of Health
2017

A.N. Pritzker Professorship
University of Chicago
2008 - pres

Howard Hughes Medical Investigator
2005 - 2013

Cancer Research Institute Investigator Award
1995 - 1998

Mallinkrodt Foundation Award
1994 - 1997

Gold Medal of the Residency Program
Assistance Publique Hopitaux de Paris
1988

Oulmont, Laval, Dreyfous Prize
Academie of Medicine Paris
1988