People

Albert Bendelac, MD PhD

  • A.N. Pritzker Distinguished Service Professor of Pathology
  • Research and Scholarly Interests: B cells, Innate lymphocytes, Intestinal IgA B cells, Intestinal intraepithelial T cells, Lymphocyte development, Microbiome, NKT cells, T cells
  • Websites: Bendelac Lab, Research Network Profile
  • Contact: abendela@bsd.uchicago.edu

Our laboratory studies the populations of lymphocytes that reside at mucosal barriers and perform rapid innate-like functions to maintain homeostasis and protect against infection, injury and tumor. We use developmental biology and genetic engineering to define the identity and track the function of multiple ‘unconventional’ populations including NKT cells, MAIT cells, gamma-delta T cells, innate lymphoid cells, intraepithelial intestinal T lymphocytes and IgA producing intestinal B cells. Ultimately, these studies help identify the central relationships between immunity and microbiome at the intestinal barrier.

University Paris VII
Paris, France
PhD - Immunology
1992

University Paris VI
Paris, France
MD - Medicine
1985

B cell superantigens in the human intestinal microbiota.
Bunker JJ, Drees C, Watson AR, Plunkett CH, Nagler CR, Schneewind O, Eren AM, Bendelac A. B cell superantigens in the human intestinal microbiota. Sci Transl Med. 2019 Aug 28; 11(507).
PMID: 31462512

IgA Responses to Microbiota.
Bunker JJ, Bendelac A. IgA Responses to Microbiota. Immunity. 2018 08 21; 49(2):211-224.
PMID: 30134201

Diverse developmental pathways of intestinal intraepithelial lymphocytes.
McDonald BD, Jabri B, Bendelac A. Diverse developmental pathways of intestinal intraepithelial lymphocytes. Nat Rev Immunol. 2018 08; 18(8):514-525.
PMID: 29717233

Publisher Correction: A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development.
Mao AP, Ishizuka IE, Kasal DN, Mandal M, Bendelac A. Publisher Correction: A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development. Nat Commun. 2017 11 30; 8(1):1933.
PMID: 29192205

NKT cells contribute to basal IL-4 production but are not required to induce experimental asthma.
McKnight CG, Morris SC, Perkins C, Zhu Z, Hildeman DA, Bendelac A, Finkelman FD. NKT cells contribute to basal IL-4 production but are not required to induce experimental asthma. PLoS One. 2017; 12(11):e0188221.
PMID: 29182669

A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development.
Mao AP, Ishizuka IE, Kasal DN, Mandal M, Bendelac A. A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development. Nat Commun. 2017 10 16; 8(1):863.
PMID: 29038474

Natural polyreactive IgA antibodies coat the intestinal microbiota.
Bunker JJ, Erickson SA, Flynn TM, Henry C, Koval JC, Meisel M, Jabri B, Antonopoulos DA, Wilson PC, Bendelac A. Natural polyreactive IgA antibodies coat the intestinal microbiota. Science. 2017 10 20; 358(6361).
PMID: 28971969

Multiple layers of transcriptional regulation by PLZF in NKT-cell development.
Mao AP, Constantinides MG, Mathew R, Zuo Z, Chen X, Weirauch MT, Bendelac A. Multiple layers of transcriptional regulation by PLZF in NKT-cell development. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):7602-7.
PMID: 27325774

The Innate Lymphoid Cell Precursor.
Ishizuka IE, Constantinides MG, Gudjonson H, Bendelac A. The Innate Lymphoid Cell Precursor. Annu Rev Immunol. 2016 05 20; 34:299-316.
PMID: 27168240

Single-cell analysis defines the divergence between the innate lymphoid cell lineage and lymphoid tissue-inducer cell lineage.
Ishizuka IE, Chea S, Gudjonson H, Constantinides MG, Dinner AR, Bendelac A, Golub R. Single-cell analysis defines the divergence between the innate lymphoid cell lineage and lymphoid tissue-inducer cell lineage. Nat Immunol. 2016 Mar; 17(3):269-76.
PMID: 26779601

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Quantrell Teaching Award
University of Chicago
2019

MERIT Award
National Institutes of Health
2017

A.N. Pritzker Professorship
University of Chicago
2008 - pres

Howard Hughes Medical Investigator
2005 - 2013

Cancer Research Institute Investigator Award
1995 - 1998

Mallinkrodt Foundation Award
1994 - 1997

Gold Medal of the Residency Program
Assistance Publique Hopitaux de Paris
1988

Oulmont, Laval, Dreyfous Prize
Academie of Medicine Paris
1988