My lab focuses on computational immunology and machine learning, with an emphasis on building predictive models of human immunology. We develop computational methods to understand immune responses across scales by analyzing both the molecular programs within immune cells and their interactions with the tissue microenvironment. Our goal is to uncover clinically relevant insights and pave the way for new diagnostics and therapies that can improve human health.
Improved Diagnosis of Non-Melanoma Skin Cancer in Resource-Limited Settings.
Improved Diagnosis of Non-Melanoma Skin Cancer in Resource-Limited Settings. Cancer Epidemiol Biomarkers Prev. 2025 Apr 27.
PMID: 40287980
Rare variant contribution to the heritability of coronary artery disease.
Rare variant contribution to the heritability of coronary artery disease. Nat Commun. 2024 10 09; 15(1):8741.
PMID: 39384761
Androgens contribute to sex bias of autoimmunity in mice by T cell-intrinsic regulation of Ptpn22 phosphatase expression.
Androgens contribute to sex bias of autoimmunity in mice by T cell-intrinsic regulation of Ptpn22 phosphatase expression. Nat Commun. 2024 Sep 03; 15(1):7688.
PMID: 39227386
Isotype-aware inference of B cell clonal lineage trees from single-cell sequencing data.
Isotype-aware inference of B cell clonal lineage trees from single-cell sequencing data. Cell Genom. 2024 Sep 11; 4(9):100637.
PMID: 39208795
Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk.
Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk. medRxiv. 2024 Jun 26.
PMID: 37645892
Computational prediction of protein interactions in single cells by proximity sequencing.
Computational prediction of protein interactions in single cells by proximity sequencing. PLoS Comput Biol. 2024 Mar; 20(3):e1011915.
PMID: 38483861
TRIBAL: Tree Inference of B cell Clonal Lineages.
TRIBAL: Tree Inference of B cell Clonal Lineages. bioRxiv. 2023 Nov 27.
PMID: 38076836
Full-length Isoform Sequencing for Resolving the Molecular Basis of Charcot-Marie-Tooth 2A.
Full-length Isoform Sequencing for Resolving the Molecular Basis of Charcot-Marie-Tooth 2A. Neurol Genet. 2023 Oct; 9(5):e200090.
PMID: 37560121
Perceptions of forensic scientists on statistical models, sequence data, and ethical implications for DNA evidence evaluations: A qualitative assessment.
Perceptions of forensic scientists on statistical models, sequence data, and ethical implications for DNA evidence evaluations: A qualitative assessment. Forensic Sci Int Synerg. 2023; 6:100335.
PMID: 37325613
Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups.
Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups. Nat Commun. 2023 06 02; 14(1):3202.
PMID: 37268629