The McNerney lab studies the genomic changes in blood cancers with the goal of identifying therapeutic vulnerabilities. We focus on myeloid malignancies which are particularly difficult to treat. We apply a variety of functional genomics approaches and model systems to decipher changes in the cancer genome. Ongoing and available projects include studies of hematopoietic stem cell regulation, gene regulation during hematopoiesis, contiguous gene syndromes in cancer, and oncogenic signaling. Please visit our webpage for more information https://voices.uchicago.edu/mcnerneylab/
The University of Chicago
Chicago
Postdoctoral - Genomics and Systems Biology
2014
The University of Chicago
Chicago
Residency - Clinical Pathology
2010
The University of Chicago
Chicago
MD - Medicine
2007
The University of Chicago
Chicago
PhD - Immunology
2005
Northwestern University
Evanston
B.A. - Molecular and Cellular Biology
1999
Haploinsufficient Transcription Factors in Myeloid Neoplasms.
Haploinsufficient Transcription Factors in Myeloid Neoplasms. Annu Rev Pathol. 2024 Jan 24; 19:571-598.
PMID: 37906947
Oncogenic RAS promotes leukemic transformation of CUX1-deficient cells.
Oncogenic RAS promotes leukemic transformation of CUX1-deficient cells. Oncogene. 2023 03; 42(12):881-893.
PMID: 36725889
Inherited cancer predisposing mutations in patients with therapy-related myeloid neoplasms.
Inherited cancer predisposing mutations in patients with therapy-related myeloid neoplasms. Br J Haematol. 2023 02; 200(4):489-493.
PMID: 36349721
EGR1 Haploinsufficiency Confers a Fitness Advantage to Hematopoietic Stem Cells Following Chemotherapy.
EGR1 Haploinsufficiency Confers a Fitness Advantage to Hematopoietic Stem Cells Following Chemotherapy. Exp Hematol. 2022 11; 115:54-67.
PMID: 35995095
The significance of CUX1 and chromosome 7 in myeloid malignancies.
The significance of CUX1 and chromosome 7 in myeloid malignancies. Curr Opin Hematol. 2022 03 01; 29(2):92-102.
PMID: 35084368
CRISPR screening in human hematopoietic stem and progenitor cells reveals an enrichment for tumor suppressor genes within chromosome 7 commonly deleted regions.
CRISPR screening in human hematopoietic stem and progenitor cells reveals an enrichment for tumor suppressor genes within chromosome 7 commonly deleted regions. Leukemia. 2022 05; 36(5):1421-1425.
PMID: 35034954
Genomic studies controvert the existence of the CUX1 p75 isoform.
Genomic studies controvert the existence of the CUX1 p75 isoform. Sci Rep. 2022 01 07; 12(1):151.
PMID: 34997000
Venetoclax imparts distinct cell death sensitivity and adaptivity patterns in T cells.
Venetoclax imparts distinct cell death sensitivity and adaptivity patterns in T cells. Cell Death Dis. 2021 10 27; 12(11):1005.
PMID: 34707089
Loss of a 7q gene, CUX1, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms.
Loss of a 7q gene, CUX1, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms. Blood. 2021 09 02; 138(9):790-805.
PMID: 34473231
Loss of a 7q gene, CUX1, disrupts epigenetic-driven DNA repair and drives therapy-related myeloid neoplasms.
Loss of a 7q gene, CUX1, disrupts epigenetic-driven DNA repair and drives therapy-related myeloid neoplasms. Blood. 2021 May 26.
PMID: 34041524
Leukemia and Lymphoma Society Scholar Award
2022
Faculty Award for Excellence in Graduate Teaching and Mentoring
2020
American Cancer Society Research Scholar Award
2019
American Society of Hematology Junior Faculty Scholar Award
2017
Nachman Fellow, Dept. of Pediatrics Hematology-Oncology
2015
“V” Foundation in Cancer Research Scholar Award
2014
Leukemia and Lymphoma Society, Illinois Chapter Researcher of the Year
2013
Evans Travel Award, FASEB Hematologic Malignancies Science Research Conference
2013
Cancer Research Foundation Young Investigator Award
2013
Leukemia and Lymphoma Society Fellow Award
2011
Robert W. Wissler Fellowship Award, Department of Pathology
2010
Resident Research Grant, College of American Pathologists
2009
Leon Jacobson Prize for Senior Scientific Presentation, Pritzker School of Medicine
2007
Honorable Mention Best PhD Dissertation Award, Biological Sciences, University of Chicago
2006
Committee on Immunology Best PhD Thesis Award, University of Chicago
2006
Robert E. Priest Pathology Merit Award, Department of Pathology, University of Chicago
2005
Doolittle-Harrison Travel Fellowship, University of Chicago
2004
Elaine Frank Family Fellowship for Medical Research, MSTP, University of Chicago
2003
Medical Scientist Training Program, NIH
2000 - 2007
Graduation with Departmental Honors, Biological Sciences, Northwestern University
1999
Graduation Cum Laude, Northwestern University
1999
Edgar Macey Scholarship for Summer Research, Northwestern University
1997