People

Susana G. Marino, MD PhD

  • Professor of Pathology
  • Research and Scholarly Interests: Heart, lung, kidney, and liver transplantation, Hematopoietic cell transplantation, Histocompatibility and immunogenetics, Immunological risk, Permissive and non-permissive mismatches, Transplantation Immunobiology
  • Websites: Research Network Profile
  • Contact: smarino@bsd.uchicago.edu

Dr. Marino is a Professor in the Department of Pathology at the University of Chicago, Biological Sciences Division, the founding Director of the Transplant Immunology and Immunogenetics Laboratory Section, and the Program Director of the American Society for Histocompatibility and Immunogenetics approved Histocompatibility and Immunogenetics Fellowship. She is certified by the American Board for Histocompatibility and Immunogenetics



Dr. Marino has identified, characterized, and published several new HLA alleles, co-authored book chapters, and published manuscripts in peer-reviewed scientific journals. She has been an invited speaker at local, national, and international meetings. Her primary clinical research interests are identifying pre-and post-transplant biomarkers of immunological risk to increase access and survival to solid organ transplant patients and to use genomic markers for hematopoietic cell transplant donor selection to reduce incidence and severity of graft-versus-host disease and to increase patient survival. In collaboration with the National Marrow Donor Program and the Center for International Blood and Marrow Transplant Research, Dr. Marino has identified permissive mismatches in hematopoietic cell transplantation and recently published the guidelines for the selection of Unrelated Donors and Cord Blood Units for Hematopoietic Cell Transplantation.

High-resolution HLA allele and haplotype frequencies in several unrelated populations determined by next generation sequencing: 17th International HLA and Immunogenetics Workshop joint report.
Creary LE, Sacchi N, Mazzocco M, Morris GP, Montero-Martin G, Chong W, Brown CJ, Dinou A, Stavropoulos-Giokas C, Gorodezky C, Narayan S, Periathiruvadi S, Thomas R, De Santis D, Pepperall J, ElGhazali GE, Al Yafei Z, Askar M, Tyagi S, Kanga U, Marino SR, Planelles D, Chang CJ, Fernández-Viña MA. High-resolution HLA allele and haplotype frequencies in several unrelated populations determined by next generation sequencing: 17th International HLA and Immunogenetics Workshop joint report. Hum Immunol. 2021 Jul; 82(7):505-522.
PMID: 34030896

An association between resting state EEG parameters and the severity of topiramate-related cognitive impairment.
Barkley CM, Hu Z, Fieberg AM, Eberly LE, Birnbaum AK, Leppik IE, Marino SE. An association between resting state EEG parameters and the severity of topiramate-related cognitive impairment. Epilepsy Behav. 2021 01; 114(Pt A):107598.
PMID: 33268020

Predictors of Loss to Follow-Up Among Pediatric and Adult Hematopoietic Cell Transplantation Survivors: A Report from the Center for International Blood and Marrow Transplant Research.
Buchbinder D, Brazauskas R, Bo-Subait K, Ballen K, Parsons S, John T, Hahn T, Sharma A, Steinberg A, D'Souza A, Kumar AJ, Yoshimi A, Wirk B, Shaw B, Freytes C, LeMaistre C, Bredeson C, Dandoy C, Almaguer D, Marks DI, Szwajcer D, Hale G, Schouten H, Hashem H, Schoemans H, Murthy HS, Lazarus HM, Cerny J, Tay J, Yared JA, Adekola K, Schultz KR, Lehmann L, Burns L, Aljurf M, Diaz MA, Majhail N, Farhadfar N, Kamble R, Olsson R, Schears R, Seo S, Beattie S, Chhabra S, Savani BN, Badawy S, Ganguly S, Ciurea S, Marino S, Gergis U, Kuwatsuka Y, Inamoto Y, Khera N, Hashmi S, Wood W, Saber W. Predictors of Loss to Follow-Up Among Pediatric and Adult Hematopoietic Cell Transplantation Survivors: A Report from the Center for International Blood and Marrow Transplant Research. Biol Blood Marrow Transplant. 2020 03; 26(3):553-561.
PMID: 31726205

Effective desensitization for a strong donor-specific HLA antibody in a case of HLA-mismatched allogeneic hematopoietic cell transplantation.
Misra MK, Xin JJ, Brown NK, Weidner JG, Upchurch RL, Bishop MR, Wool GD, Artz AS, Marino SR. Effective desensitization for a strong donor-specific HLA antibody in a case of HLA-mismatched allogeneic hematopoietic cell transplantation. HLA. 2019 09; 94(3):307-311.
PMID: 31314169

Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR.
Dehn J, Spellman S, Hurley CK, Shaw BE, Barker JN, Burns LJ, Confer DL, Eapen M, Fernandez-Vina M, Hartzman R, Maiers M, Marino SR, Mueller C, Perales MA, Rajalingam R, Pidala J. Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR. Blood. 2019 09 19; 134(12):924-934.
PMID: 31292117

HLA alleles and haplotypes observed in 263 US families.
Osoegawa K, Mallempati KC, Gangavarapu S, Oki A, Gendzekhadze K, Marino SR, Brown NK, Bettinotti MP, Weimer ET, Montero-Martín G, Creary LE, Vayntrub TA, Chang CJ, Askar M, Mack SJ, Fernández-Viña MA. HLA alleles and haplotypes observed in 263 US families. Hum Immunol. 2019 Sep; 80(9):644-660.
PMID: 31256909

Quality control project of NGS HLA genotyping for the 17th International HLA and Immunogenetics Workshop.
Osoegawa K, Vayntrub TA, Wenda S, De Santis D, Barsakis K, Ivanova M, Hsu S, Barone J, Holdsworth R, Diviney M, Askar M, Willis A, Railton D, Laflin S, Gendzekhadze K, Oki A, Sacchi N, Mazzocco M, Andreani M, Ameen R, Stavropoulos-Giokas C, Dinou A, Torres M, Dos Santos Francisco R, Serra-Pages C, Goodridge D, Balladares S, Bettinotti MP, Iglehart B, Kashi Z, Martin R, Saw CL, Ragoussis J, Downing J, Navarrete C, Chong W, Saito K, Petrek M, Tokic S, Padros K, Beatriz Rodriguez M, Zakharova V, Shragina O, Marino SR, Brown NK, Shiina T, Suzuki S, Spierings E, Zhang Q, Yin Y, Morris GP, Hernandez A, Ruiz P, Khor SS, Tokunaga K, Geretz A, Thomas R, Yamamoto F, Mallempati KC, Gangavarapu S, Kanga U, Tyagi S, Marsh SGE, Bultitude WP, Liu X, Cao D, Penning M, Hurley CK, Cesbron A, Mueller C, Mytilineos J, Weimer ET, Bengtsson M, Fischer G, Hansen JA, Chang CJ, Mack SJ, Creary LE, Fernandez-Viña MA. Quality control project of NGS HLA genotyping for the 17th International HLA and Immunogenetics Workshop. Hum Immunol. 2019 Apr; 80(4):228-236.
PMID: 30738112

Reanalysis of the role of pronase treatment of B cells in the flow cytometric crossmatch assay: Fc receptor is not the primary target.
Brown NK, Meade JR, Wang J, Marino SR. Reanalysis of the role of pronase treatment of B cells in the flow cytometric crossmatch assay: Fc receptor is not the primary target. Hum Immunol. 2017 Nov; 78(11-12):704-709.
PMID: 28987959

Clinical risks and healthcare utilization of hematopoietic cell transplantation for sickle cell disease in the USA using merged databases.
Arnold SD, Brazauskas R, He N, Li Y, Aplenc R, Jin Z, Hall M, Atsuta Y, Dalal J, Hahn T, Khera N, Bonfim C, Majhail NS, Diaz MA, Freytes CO, Wood WA, Savani BN, Kamble RT, Parsons S, Ahmed I, Sullivan K, Beattie S, Dandoy C, Munker R, Marino S, Bitan M, Abdel-Azim H, Aljurf M, Olsson RF, Joshi S, Buchbinder D, Eckrich MJ, Hashmi S, Lazarus H, Marks DI, Steinberg A, Saad A, Gergis U, Krishnamurti L, Abraham A, Rangarajan HG, Walters M, Lipscomb J, Saber W, Satwani P. Clinical risks and healthcare utilization of hematopoietic cell transplantation for sickle cell disease in the USA using merged databases. Haematologica. 2017 11; 102(11):1823-1832.
PMID: 28818869

EDTA is superior to DTT treatment for overcoming the prozone effect in HLA antibody testing.
Wang J, Meade JR, Brown NK, Weidner JG, Marino SR. EDTA is superior to DTT treatment for overcoming the prozone effect in HLA antibody testing. HLA. 2017 02; 89(2):82-89.
PMID: 28102038

View All Publications

Principal Investigator:Computational Simulation Tools to Predict Donor Compatibility in Hematopoieti
Center for International Blood and Marrow Transplant Research (CIBMTR)
2015 - 2017

Principal Investigator: Effects of HLA class I amino acid mismatches on stem cell transplant outcome
Center for International Blood and Marrow Transplant Research (CIBMTR)
2013 - 2017

Principal Investigator: HLA mismatches at the amino acid level on hematopoietic stem cell transplant
Center for International Blood and Marrow Transplant Research (CIBMTR)
2007 - 2017

Principal Investigator: HLA matching in pediatric unrelated umbilical cord blood transplantation.
Center for International Blood and Marrow Transplant Research (CIBMTR)
2004

Principal Investigator: DNA-based HLA class I typing contract.
National Marrow Donor Program (NMDP)
1997 - 1998

Principal Investigator: DNA-based HLA class II typing contract.
National Marrow Donor Program (NMDP)
1995 - 1998

Qualitas Award, Dr. Alfredo Lanari
Academy Nacional of Sciences. Argentina
1990

1st Place, Best Thesis Annual School of Medicine
University of Buenos Aires
1989

Scholarship Recipient
Canadian Heart Foundation
1987

Scholar Recipient (not accepted)
The Kidney Foundation of Canada
1987

Senior Scholarship Recipient
National Council of Scientific and Technical Research, Argentina
1985

Junior Scholarship Recipient
National Council of Scientific and Technical Research, Argentina
1983