People

Arjun Raman, MD PhD

Biological systems are thought to be exceedingly 'complex'--comprised of many parts and sets of unintuitive interactions between parts conferring system function. My lab is interested in elucidating principles of structure, function, and adaptability relationships with the ultimate goals of (i) characterizing 'personalized' variation in biological systems with high-fidelity, (ii) creating tools to genetically engineer variation in a rational way, and (iii) engineering natural-like, adaptive systems de novo. We use a blend of theory, computation, and experiment applied to a range of model systems spanning neural networks to electronic health record data to complex ecosystems inhabiting humans in addressing these concepts.

Washington University in St. Louis
St. Louis
- Clinical Pathology
2020

University of Texas at Southwestern
Dallas
M.D. - Medicine
2017

University of Texas at Southwestern
Dallas
Ph.D. - Molecular Biophysics
2017

University of Chicago
Chicago
B.A. - Physics
2008

University of Chicago
Chicago
B.S. - Chemistry (Honors)
2008

A Microbiota-Directed Food Intervention for Undernourished Children.
Chen RY, Mostafa I, Hibberd MC, Das S, Mahfuz M, Naila NN, Islam MM, Huq S, Alam MA, Zaman MU, Raman AS, Webber D, Zhou C, Sundaresan V, Ahsan K, Meier MF, Barratt MJ, Ahmed T, Gordon JI. A Microbiota-Directed Food Intervention for Undernourished Children. N Engl J Med. 2021 04 22; 384(16):1517-1528.
PMID: 33826814

Understanding the mother-breastmilk-infant "triad".
Bode L, Raman AS, Murch SH, Rollins NC, Gordon JI. Understanding the mother-breastmilk-infant "triad". Science. 2020 03 06; 367(6482):1070-1072.
PMID: 32139527

Identifying determinants of bacterial fitness in a model of human gut microbial succession.
Feng L, Raman AS, Hibberd MC, Cheng J, Griffin NW, Peng Y, Leyn SA, Rodionov DA, Osterman AL, Gordon JI. Identifying determinants of bacterial fitness in a model of human gut microbial succession. Proc Natl Acad Sci U S A. 2020 02 04; 117(5):2622-2633.
PMID: 31969452

A sparse covarying unit that describes healthy and impaired human gut microbiota development.
Raman AS, Gehrig JL, Venkatesh S, Chang HW, Hibberd MC, Subramanian S, Kang G, Bessong PO, Lima AAM, Kosek MN, Petri WA, Rodionov DA, Arzamasov AA, Leyn SA, Osterman AL, Huq S, Mostafa I, Islam M, Mahfuz M, Haque R, Ahmed T, Barratt MJ, Gordon JI. A sparse covarying unit that describes healthy and impaired human gut microbiota development. Science. 2019 07 12; 365(6449).
PMID: 31296739

Origins of Allostery and Evolvability in Proteins: A Case Study.
Raman AS, White KI, Ranganathan R. Origins of Allostery and Evolvability in Proteins: A Case Study. Cell. 2016 Jul 14; 166(2):468-480.
PMID: 27321669

The spatial architecture of protein function and adaptation.
McLaughlin RN, Poelwijk FJ, Raman A, Gosal WS, Ranganathan R. The spatial architecture of protein function and adaptation. Nature. 2012 Nov 01; 491(7422):138-42.
PMID: 23041932

Photofragment imaging study of the CH2CCH2OH radical intermediate of the OH+allene reaction.
Raman AS, Bell MJ, Lau KC, Butler LJ. Photofragment imaging study of the CH2CCH2OH radical intermediate of the OH+allene reaction. J Chem Phys. 2007 Oct 21; 127(15):154316.
PMID: 17949158