Dr. Weber is an expert in the biophysical properties of the tight junctions and focuses on defining mechanisms of claudin barrier regulation in health and disease.
A second focus of Dr. Weber's lab is cardiac cellular electrophysiology, with an emphasis on mechanisms of abnormal cellular calcium handling in disease.
University of Chicago Medicine
Fellowship - Gastrointestinal Pathology
2010
University of Chicago Medicine
Residency - Anatomic Pathology
2007
Loyola University Chicago, Stritch School of Medicine
MD, PhD - Physiology
2004
A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.
A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network. Circulation. 2024 Apr 09; 149(15):1205-1230.
PMID: 38189150
ATAT: Automated Tissue Alignment and Traversal in Spatial Transcriptomics with Self-Supervised Learning.
ATAT: Automated Tissue Alignment and Traversal in Spatial Transcriptomics with Self-Supervised Learning. bioRxiv. 2023 Dec 10.
PMID: 38106010
Potential Dietary and Therapeutic Strategies Involving Indole-3-Carbinole in Preclinical Models of Intestinal Inflammation.
Potential Dietary and Therapeutic Strategies Involving Indole-3-Carbinole in Preclinical Models of Intestinal Inflammation. Nutrients. 2023 Nov 30; 15(23).
PMID: 38068838
Multiomic analysis reveals cellular and epigenetic plasticity in intestinal pouches of ulcerative colitis patients.
Multiomic analysis reveals cellular and epigenetic plasticity in intestinal pouches of ulcerative colitis patients. medRxiv. 2023 Nov 13.
PMID: 38014192
Ozanimod-Exposed Patients with Ulcerative Colitis Undergoing Total Colectomy Exhibit Unique Lymph Node Histologic Changes.
Ozanimod-Exposed Patients with Ulcerative Colitis Undergoing Total Colectomy Exhibit Unique Lymph Node Histologic Changes. J Crohns Colitis. 2023 Oct 25.
PMID: 37879626
Inflammation in the proximal colon is a risk factor for the development of colorectal neoplasia in inflammatory bowel disease patients with primary sclerosing cholangitis.
Inflammation in the proximal colon is a risk factor for the development of colorectal neoplasia in inflammatory bowel disease patients with primary sclerosing cholangitis. Therap Adv Gastroenterol. 2023; 16:17562848231184985.
PMID: 37692199
Molecular dynamics analyses of CLDN15 pore size and charge selectivity.
Molecular dynamics analyses of CLDN15 pore size and charge selectivity. bioRxiv. 2023 Aug 17.
PMID: 37645840
Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis.
Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis. Nat Med. 2023 Jun; 29(6):1520-1529.
PMID: 37322120
OrganoID: A versatile deep learning platform for tracking and analysis of single-organoid dynamics.
OrganoID: A versatile deep learning platform for tracking and analysis of single-organoid dynamics. PLoS Comput Biol. 2022 11; 18(11):e1010584.
PMID: 36350878
Molecular mechanism of claudin-15 strand flexibility: A computational study.
Molecular mechanism of claudin-15 strand flexibility: A computational study. J Gen Physiol. 2022 12 05; 154(12).
PMID: 36318156