Dr. Weber is an expert in the biophysical properties of the tight junctions and focuses on defining mechanisms of claudin barrier regulation in health and disease.
A second focus of Dr. Weber's lab is cardiac cellular electrophysiology, with an emphasis on mechanisms of abnormal cellular calcium handling in disease.
University of Chicago Medicine
Fellowship - Gastrointestinal Pathology
2010
University of Chicago Medicine
Residency - Anatomic Pathology
2007
Loyola University Chicago, Stritch School of Medicine
MD, PhD - Physiology
2004
Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer.
Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer. bioRxiv. 2025 Sep 08.
PMID: 40964288
Histopathologic Evaluation and Single-cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients With Inflammatory Bowel Disease.
Histopathologic Evaluation and Single-cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients With Inflammatory Bowel Disease. Cell Mol Gastroenterol Hepatol. 2025; 19(10):101563.
PMID: 40571096
Deployment of an Artificial Intelligence Histology Tool to Aid Qualitative Assessment of Histopathology Using the Nancy Histopathology Index in Ulcerative Colitis.
Deployment of an Artificial Intelligence Histology Tool to Aid Qualitative Assessment of Histopathology Using the Nancy Histopathology Index in Ulcerative Colitis. Inflamm Bowel Dis. 2025 Jun 13; 31(6):1630-1636.
PMID: 39284932
Molecular dynamics analyses of CLDN15 pore size and charge selectivity.
Molecular dynamics analyses of CLDN15 pore size and charge selectivity. bioRxiv. 2025 Apr 30.
PMID: 37645840
Histopathologic Evaluation and Single-Cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients with Inflammatory Bowel Disease.
Histopathologic Evaluation and Single-Cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients with Inflammatory Bowel Disease. bioRxiv. 2025 Jan 28.
PMID: 39974918
Multiomic analysis reveals cellular, transcriptomic and epigenetic changes in intestinal pouches of ulcerative colitis patients.
Multiomic analysis reveals cellular, transcriptomic and epigenetic changes in intestinal pouches of ulcerative colitis patients. Nat Commun. 2025 Jan 21; 16(1):904.
PMID: 39837850
Multiomic analysis reveals cellular, transcriptomic and epigenetic changes in intestinal pouches of ulcerative colitis patients.
Multiomic analysis reveals cellular, transcriptomic and epigenetic changes in intestinal pouches of ulcerative colitis patients. medRxiv. 2025 Jan 09.
PMID: 38014192
Inflammation-Induced Claudin-2 Upregulation Limits Pancreatitis Progression by Enhancing Tight Junction-Controlled Pancreatic Ductal Transport.
Inflammation-Induced Claudin-2 Upregulation Limits Pancreatitis Progression by Enhancing Tight Junction-Controlled Pancreatic Ductal Transport. bioRxiv. 2024 Nov 13.
PMID: 39605652
Deployment of an Artificial Intelligence Histology Tool to Aid Qualitative Assessment of Histopathology Using the Nancy Histopathology Index in Ulcerative Colitis.
Deployment of an Artificial Intelligence Histology Tool to Aid Qualitative Assessment of Histopathology Using the Nancy Histopathology Index in Ulcerative Colitis. Inflamm Bowel Dis. 2024 Sep 16.
PMID: 39284932
Decentralized clinical trials for medications to reduce the risk of dementia: Consensus report and guidance.
Decentralized clinical trials for medications to reduce the risk of dementia: Consensus report and guidance. Alzheimers Dement. 2024 07; 20(7):4625-4634.
PMID: 38824659