We are a multidisciplinary team with a passion for understanding immune T-cell responses in health and diseases. We study Tregs, unique cells in our body that specialize in preventing autoimmune diseases. We take the unique perspective to look at cellular interactions, i.e. how Tregs talk to other cells to do maintain tolerance, promote tissue homeostasis, and contribute to pathogenesis. We explore the role of Tregs directly in human tissues using Systems and Synthetic Biology approaches that illuminate these interactions.
Shared Clonal Origin of Multiple Histiocytic and Dendritic Neoplasms and Polycythemia Vera, Follicular Lymphoma in 1 Patient.
Shared Clonal Origin of Multiple Histiocytic and Dendritic Neoplasms and Polycythemia Vera, Follicular Lymphoma in 1 Patient. Am J Dermatopathol. 2022 12 01; 44(12):929-932.
PMID: 35642960
The ImmGen consortium OpenSource T cell project.
The ImmGen consortium OpenSource T cell project. Nat Immunol. 2022 05; 23(5):643-644.
PMID: 35469020
Analysis of the Effectiveness of the Ad26.COV2.S Adenoviral Vector Vaccine for Preventing COVID-19.
Analysis of the Effectiveness of the Ad26.COV2.S Adenoviral Vector Vaccine for Preventing COVID-19. JAMA Netw Open. 2021 11 01; 4(11):e2132540.
PMID: 34726743
Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis.
Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis. JCI Insight. 2021 09 22; 6(18).
PMID: 34403365
NLRP3 Inflammasome Mediates Immune-Stromal Interactions in Vasculitis.
NLRP3 Inflammasome Mediates Immune-Stromal Interactions in Vasculitis. Circ Res. 2021 10 15; 129(9):e183-e200.
PMID: 34517723
Mapping each pre-existing condition's association to short-term and long-term COVID-19 complications.
Mapping each pre-existing condition's association to short-term and long-term COVID-19 complications. NPJ Digit Med. 2021 Jul 27; 4(1):117.
PMID: 34315980
A Literature-Derived Knowledge Graph Augments the Interpretation of Single Cell RNA-seq Datasets.
A Literature-Derived Knowledge Graph Augments the Interpretation of Single Cell RNA-seq Datasets. Genes (Basel). 2021 06 10; 12(6).
PMID: 34200671
Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations.
Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations. Nat Immunol. 2021 05; 22(5):607-619.
PMID: 33833438
Knowledge synthesis of 100 million biomedical documents augments the deep expression profiling of coronavirus receptors.
Knowledge synthesis of 100 million biomedical documents augments the deep expression profiling of coronavirus receptors. Elife. 2020 05 28; 9.
PMID: 32463365
CD4+ teff cell heterogeneity: the perspective from single-cell transcriptomics.
CD4+ teff cell heterogeneity: the perspective from single-cell transcriptomics. Curr Opin Immunol. 2020 04; 63:61-67.
PMID: 32259715