We are a multidisciplinary team with a passion for understanding immune T-cell responses in health and diseases. We study Tregs, unique cells in our body that specialize in preventing autoimmune diseases. We take the unique perspective to look at cellular interactions, i.e. how Tregs talk to other cells to do maintain tolerance, promote tissue homeostasis, and contribute to pathogenesis. We explore the role of Tregs directly in human tissues using Systems and Synthetic Biology approaches that illuminate these interactions.
Histopathologic Evaluation and Single-Cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients with Inflammatory Bowel Disease.
Histopathologic Evaluation and Single-Cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients with Inflammatory Bowel Disease. bioRxiv. 2025 Jan 28.
PMID: 39974918
NK cells restrain cytotoxic CD8+ T cells in the submandibular gland via PD-1-PD-L1.
NK cells restrain cytotoxic CD8+ T cells in the submandibular gland via PD-1-PD-L1. Sci Immunol. 2024 12 20; 9(102):eadl2967.
PMID: 39705335
Cutaneous Manifestations of Myeloid Neoplasms Exhibit Broad and Divergent Morphologic and Immunophenotypic Features but Share Ancestral Clonal Mutations With Bone Marrow.
Cutaneous Manifestations of Myeloid Neoplasms Exhibit Broad and Divergent Morphologic and Immunophenotypic Features but Share Ancestral Clonal Mutations With Bone Marrow. Mod Pathol. 2024 Jan; 37(1):100352.
PMID: 37839675
Shared Clonal Origin of Multiple Histiocytic and Dendritic Neoplasms and Polycythemia Vera, Follicular Lymphoma in 1 Patient.
Shared Clonal Origin of Multiple Histiocytic and Dendritic Neoplasms and Polycythemia Vera, Follicular Lymphoma in 1 Patient. Am J Dermatopathol. 2022 12 01; 44(12):929-932.
PMID: 35642960
The ImmGen consortium OpenSource T cell project.
The ImmGen consortium OpenSource T cell project. Nat Immunol. 2022 05; 23(5):643-644.
PMID: 35469020
Analysis of the Effectiveness of the Ad26.COV2.S Adenoviral Vector Vaccine for Preventing COVID-19.
Analysis of the Effectiveness of the Ad26.COV2.S Adenoviral Vector Vaccine for Preventing COVID-19. JAMA Netw Open. 2021 11 01; 4(11):e2132540.
PMID: 34726743
Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis.
Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis. JCI Insight. 2021 09 22; 6(18).
PMID: 34403365
NLRP3 Inflammasome Mediates Immune-Stromal Interactions in Vasculitis.
NLRP3 Inflammasome Mediates Immune-Stromal Interactions in Vasculitis. Circ Res. 2021 10 15; 129(9):e183-e200.
PMID: 34517723
Mapping each pre-existing condition's association to short-term and long-term COVID-19 complications.
Mapping each pre-existing condition's association to short-term and long-term COVID-19 complications. NPJ Digit Med. 2021 Jul 27; 4(1):117.
PMID: 34315980
A Literature-Derived Knowledge Graph Augments the Interpretation of Single Cell RNA-seq Datasets.
A Literature-Derived Knowledge Graph Augments the Interpretation of Single Cell RNA-seq Datasets. Genes (Basel). 2021 06 10; 12(6).
PMID: 34200671